In a screen for genes that affect the metabolic response to high-fat diet (HFD), we selected one line of N-ethyl-N-nitrosourea (ENU)-mutagenized mice, Jll, with dominantly inherited resistance to diet-induced obesity (DIO).Mutant animals had dramatically reduced body weight and fat mass, and low basal insulin and glucose levels relative to unaffect
Abstract Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies.Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral regions in the human brain.3D T2-Fluid Attenuated Inversion Recovery magnetic resonance
Summary: Regulatory T (Treg) cell defects are implicated in disorders of embryo implantation and placental development, but the origins of Treg cell dysfunction are unknown.Here, we comprehensively analyzed the phenotypes and transcriptional profile of peripheral 7896001020030 blood Treg cells in individuals with early pregnancy failure (EPF).Compa